One scientific information in support of their

     One of the most valuable componentsof indigenous medical systems for over 40 centuries, has been the Mangifera indicaleaves, the largest fruit-bearing tree ever discovered in India. Theusage of Mangifera indica leaves as amedicinal agent dates back to as early as327 BCE. The existence of some majorgroups of phytochemical constituents such as saponins, anthraquinones, terpenoids,etc. and therapeutically active components such as mangiferin, stigmasterol, friedelin, lupeol, etc. have also been reported from Mangifera indicaleaves.      Thereis a scarcity of scientific information in support of their success, whilst theleaves have been traditionally used as an antibacterialand immunomodulatory agent. Mangifera indica leaves are also used as anantibacterial agent in Nigerian folk herbalism.

To ascertain whether or not there is a scientific basis for this use, the effect of the blood glucose level was evaluated in normoglycaemic,glucose-induced hyperglycaemic and streptozotocin(STZ) induced diabetic rodents such as Rattus (rat). The aqueous extractgiven orally did not modify the blood glucose levels in either normoglycaemicor STZ-induced (streptozotocin) diabetic rodents specifically Rattus (rat).     Aqueous extracts of Mangifera indica leaves showed remarkable influence on reproductive functions,wound regeneration and antidiabetic tasks. Alcoholic extracts of Mangiferaindica leaves have been found containing TNF- (Tumor necrosis factor), ILIBexpression and B-lactamase producing entericbacterial development.      Mangifera indica leaves are equipped witha broad outer cuticle to avoid the loss of nutrientsand to prevent wetting when it’sraining. Furthermore, Mangifera indicaleaves are found alternating on the plant stalk to exploit the light energy acquired from the sun. This is because of thefact that Mangifera indica develops best when exposed to sunlight.

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