Increase are present.3 They contain several medicinal

Increase in multi drug resistantbacteria had led to the need to search for new antimicrobials has increased.Currently there has been increase in natural and herbal medicine because of itslesser side effects and reduced toxicity.1 Curry leaves scientifically known as Murraya koenigii are a popularleaf-spice. It is a tropical to sub-tropical tree in the family Rutaceae. It has a distinct aroma due to thepresence of volatile oil.

The leaves have a slightly pungent, bitter in taste,and acidic in nature. Curry leaf is also used in many traditional culturesnamely Indian, Ayurvedic and Unani prescriptions.2 Thecurry leaves contain proteins, carbohydrate, fiber, minerals, carotene,nicotinic acid, Vitamin C, Vitamin A, calcium and oxalic acid. It also containscrystalline glycosides, carbazole alkaloids, koenigin, girinimbin,iso-mahanimbin, koenine, koenidine and koenimbine, Triterpenoid alkaloids cyclomahanimbine,tetrahydromahanimbine. Murrayastine, murrayaline, pyrayafoline carbazolealkaloids and many other chemicals are present.3 Theycontain several medicinal properties such as antidiabetic, antioxidant, antimicrobial,anti-fungal, anti-inflammatory, anti- carcinogenic and hepato-protective properties.

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Bacteria are the etiological agents of periodontaldiseases, which remain the primary cause of tooth loss in adults. Periodontal diseases are usually initiated by plaque biofilm formationwhich in turn gets mineralized into calculus. This plaque biofilm and calculusact as a resident for many pathologic and physiologic bacteria including Porphyromonasgingivalis, Staphylococcus aureus, Streptococcus sanguis, Streptococcus oralisTreponema denticoli etc. Many researches have proved the presence of Staphylococcusaureus in calculus.Staphylococcus aureus is a gram-positive, round-shaped bacterium that is a member of the Firmicutes, and it is a member of the normal flora of the body,frequently found in the nose, respiratory tract, and on the skin. It is a facultative anaerobe.

Staphylococcus aureus produces variousenzymes such as coagulase which clots plasma and coats the bacterial cell,probably to prevent phagocytosis. Hyaluronidase breaks down hyaluronic acid and helps in spreading it. Staphylococcus aureus also produces deoxyribonuclease, which breaks down the DNA, lipase to digest lipids, staphylokinase to dissolve fibrin and aid in spread, and beta-lactamase for drug resistance. Antibiotic resistant strainof Staphylococcus aureus is methicillin resistant Staphylococcus aureus4which has become a clinical problem worldwide. It is important to bring out newantibiotics against staphylococcus species.Chlorhexidine is a biguanide compoundused as an antiseptic agent with topical antibacterial activity.

 Chlorhexidine is positively charged and reacts withthe negatively charged microbial cell surface, thereby destroying the integrityof the cell membrane. Subsequently, chlorhexidine penetrates into the cell and causes leakage ofintracellular components leading to cell death. Since gram positive bacteriaare more negatively charged, they are more sensitive to this agent.

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