Helicobacter of infection in dyspepsia patients was

Helicobacter pyloriinfection is one of the most common chronic infections around the world; thiskind of infection differs from country to country 7,8. Dyspepsiais one of the most common causes of referral of patients to gastrointestinalclinics and is one of the clinical manifestations H. pylori infection inthe gastrointestinal tract, leading to a high treatment cost.

Dyspepsia isdefined as having one or more of the symptoms including heartburn, abdominaldiscomfort after eating, premature fullness, bloating and epigastric pain 22,23.Based on the results of this study, the prevalence of H. pylori infectionin patients with dyspepsia referring to the endoscopic section of ShohadayeAshayer and Shaheed Rahimi hospitals in Khorramabad was 57.

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4%, which isdifferent from some similar studies. In the study of Ahenjan et al., in 2013,the prevalence of H.

pylori infection was reported to be 54.15% in Sari 26.In a study by Arj et al.

in Kashan, the prevalence of infection in dyspepsiapatients was 66% 13. Shokrzadeh et al reported the prevalence ratein Tehran as 86.8% 15. In the study of Kargar et al., in 2014, entitled”the epidemiological study of H. pylori infection in patients withgastrointestinal disorders in Chaharmahal-o-Bakhtiari”, 82% of the subjectstested positive for H. pylori 27. A survey by Niknam et al.

in southern Iran in 2014 showed that 31% of the subjects were infected to Helicobacterpylori 14. Fallahi et al. reported a prevalence of H.pylori infection in patients with disturbances of upper gastrointestinal ductin Bushehr port as 43.

5% 28. A study by Tanih et al. in 2010 foundthat prevalence of H. pylori infection in patients with dyspepsia inSouth Africa was 66.1% 9.

Ayobanji et al. reported the prevalenceof infection in Southwest Saudi Arabia as 54.9% 10. In a report byOlokoba et al. in 2013, and a study by Jemilohu et al.

in 2010, the prevalencerates in Nigeria were 93.6% and 62% 11,29. In a study conducted inGhana by Mary et al., 52.72% of the subjects were infected by H. pylori 30.The prevalence of H.

pylori was 40.6% in South Korea, 50% in Taiwan, 20%in Australia, and 48.8% in Germany 8,12.From these findings, it can be concluded that theprevalence of H.

pylori infection in the present study is moderate andis less or more than in some studies in Iran and around the world. Differentresults in various studies can be due to the method of H. pylori infectionidentification in the target group as well as differences in crowdedness, geographical,social, economic, health, ethnic and racial profiles of the populations studied.This variation may even be observed inside a city, such that Mokhtari et al.showed that the rate of H.

pylori infection among children 1 to 7 yearsin Isfahan’s densely populated areas was about 64% and in the low populationareas was about 31% 7,8,31. In the present study, dyspepticpatients who were infected with Helicobacter pylori included 50.2% and 49.8%women. Statistically, there was no significant difference in terms of gender.

Theseresults are consistent with some studies 2, 14, 15, 27, 32. Age isone of the important factors in the prevalence of H. pylori infection.In this study, the mean age of the patients was 48.13±17.11. Although most ofthe patients with H. pylori were over 60 years old, but there was nostatistically significant relationship between infection and age which issimilar to some other studies 26,27.

An increase in infectionprevalence in people over 60 years of age is likely due to the fact that at ahigher age, the frequency of contact with infectious agents, and consequently, thechance of getting an infection are increased. It should be noted that thisbacteria attack to human by various mechanisms and, like other ones, may getresistant to antibacterial agents. This affects the eradication rate which inturn affects the prevalence rate 33,34.   The most histological changes in patients with H.

pylori were active chronic gastritis. The study of Arj et al. in Kashanshowed that chronic gastritis was the most common histological change inpatients with dyspepsia 13. In the study by Ayobanji et al. in thesouthwest Saudi Arabia, 60.1% of patients had chronic gastritis 10.A study by Olokoba et al.

in Nigeria showed that most patients suffered fromgastritis 29. Despite the existence of a rich statisticalpopulation, this study had some limitations, including the lack of access tothe history case of some patients and not using other diagnostic methods forthe Helicobacter pylori infection.


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