Danish strains, but the leading compound has

Danish etal., (2017) reported the synthesis of new sulfonamide compound,4((4chlorophenylsulfonamido)methyl) cyclohexane carboxylicacid(C14H18ClNO4S) from 4-chlororbenzene sulfonyl chloride and tranexamic acid at roomtemperature by providing basic media.

Itsmolecular structure was resoluted fromFT-IR, NMR, single-crystal X-ray and elemental analysis. Antimicrobialscreening of these compounds was carried out and results demonstrated thatthese compounds are inactive against 4 bacterial strains as well as two fungalstrains, but the leading compound has potential to behave as inhibiting agentfor ?-chymotrypsin.11Bavadi etal., (2017) carried out the synthesis of a series of compounds havingsulfonamide moiety which was dihydropyrrol-2-ones. Antibacterial activityresults demonstrated that nearly all compounds showed antibacterial activityagainst bacterial species, P.

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aeruginosa and S. epidermidis. Noticeablymost of the compounds were more active against P. aeruginosa than referencedrug (trimethoprim-sulfamethoxazole), especially one which can probably be anantibacterial agent.12Tabatabaee.

, et al (2017) reported the synthesis andcharacterization of two Schiff bases, N-(2-hydroxy-3-methoxybenzylidene)-4-methylbenzenesulfonohydrazideand N-(2-hydroxy-3-methoxybenzylidene)-4-nitrobenzenesulfonohydrazide. Antimicrobialactivity of these compounds against gram positive and gram negative bacteria,which includes Staphylococcus saprophyticus, Staphylococcus epidermidis and Proteus mirabilis, was checked and reported. The antibacterial study was carried out byusing disc diffusion method with a reference standard of Vancomycin andTrimethoprim /sulfamethoxazole.

13Ghorab et al., (2017) synthesized a new seriesof thiourea  N-(2,6-dimethoxypyrimidin-4-yl)-4-(3-(aryl) thioureido)benzenesulfonamides, which possess sulfonamide moiety. These Fluorinatedpyridine derivatives showed high anti-microbialactivity against gram-positive bacteria.MIC values of these compounds were also reported along with the docking studyresults. Docking study suggested good action as mitogenactivated protein kinase-2 inhibitor. 14Sonu et al.

, (2017) conducted a study on sulfonamides and reported the goodantimicrobial activity of 4-Amino-N-(6-methyl-benzothiazole-2-yl)-benzenesulfonamide derivatives,  4-(Benzyidene-amino)-N-(5-methyl-isoxazol-3yl)benzenesulfonamide and 4-(3,5-Dimethyl-1H-pyrazol-4-ylamino)-benzene sulfonamide. All thesecompounds have sulfonamide group as an inhibitorof folic acid synthesis in bacteria, which hinders the multiplication ofbacteria and acts as a good antimicrobialagent against many gram positive andnegative bacteria.15Himanshuet al., (2017) studied that a seriesof amide derivatives of sulphonamides were manufactured and their antimicrobialas well as anticonvulsant activities were assessed by using the Cup-plate method and MES model. Some of thecompounds demonstrated good antibacterial  action against E.

coli. Two major compounds, 4-(4-Methoxy-phenyl)-4-oxo-N-(4-Sulfomoyl-Phenyl-)butyramideand 4-(4-chloro-3-methyl-phenyl)-4-oxo-N-(4-sulfamoyl-phenyl)-butyramideshowed prominent inhibitory activity against gram-negativebacteria.16Varmaghani et al., (2017) synthesizedtwo different classes of sulfonamides by means of the electrochemical method.

The electro-oxidatively generated4-(4-aminophenyl)-3H-1,2,4-triazole-3,5(4H)-dione on reactionwith arylsulfinic acids gives sulfonamidederivatives. Direct electrochemical oxidation of 4-(4-nitrophenyl)urazole, in a divided cell in the presence of arylsulfinicacids was accomplished to synthesize the second series of sulfonamides. Both theseclasses of sulfonamides were found effective against E.

coli aeruginosa , S. aureus , Salmonella Typhi , Aspergillus niger , and Candida albicans  17Cheptea et al.,(2017) reported that according to recent researches those compounds which haveSulfonamide moiety shows different kinds of biological activities which includeantimicrobial activity significantly. Synthesis of new sulfonamides was carriedout by the condensation reaction of 5-nitroindazloe with substituted methyl phenoxyester sulphochlorides. Synthesis of 5-nitroindazole sulfonamides was carried out withhigh yields. Their chemical structures were verified by using 1H-NMRand 1 FT-IR  and theirantimicrobial potential were checked andit was concluded that sulfonamide derivatives of 5-nitroindazole hold noticeable antibacterial activity.18De Oliveir et al.

, (2016) derived nine new sulfonamides from carvacolin good yields (76% to 92%). Thesecompounds were characterized by usingspectroscopic and spectrometric methods. Three of these compounds showedtremendous antibacterial activity against drug-resistantbacteria (S.aureus). Sulfonamidederivatives of 4-methylaniline and 4-fluoroaniline possess good activity against drug-resistant bacteria, when combinedtetracycline and ampicillin. Best antibacterial results were given by 4-methylaniline derivatives in combination witherythromycin. Carvacrol in combination with antibiotics is also tested butshowed no effect.



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